Post-mortem examination.- Body not wasted ; face olive brown colour ; genital organs very dark ; body and limbs only slightly discoloured. One or two lobules at the apex of the right lung were found to be white and consolidated ; the other viscera were healthy. The stomach had a considerable quantity of tenacious mucus covering its membrane. There were numerous patches of arborescent injection of the capilaries, and some points of ecchymosis ; this was most marked at the greater curvature. The mucous membrane of the first part of the duodenum was injected, and Brunner’s glands were remarkably distinct. The supra-renal capsules were much enlarged, hard, and dense, their external surface was irregular, and the section presented dense, whitish, semi-translucent tissue, with yellowish, cheesy matter ; also some cretaceous material. The nerves, as they entered the capsule, appeared contracted in the fibrous deposit, but the semi-lunar ganglia had their usual appearance.

Case 23.- The following is a most marked example of the disease. In reference to it, I may say that Mr. Stedman, who sent the specimen, was formerly a practitioner in Southwark, and a frequent visitor at Guy’s Hospital. He thus became conversant with the disease, and his ready diagnosis is accounted for. It will be seen in his description of the case that only one supra-renal capsule could be found, and he enquires of me the cause of the absence of the other. In answer to this, I may state that cases are recorded where no supra-renal capsules existed in the body, and this has been already used as an argument against Addison’s conclusions as to their importance in the animal economy. It has, however, never yet fallen to my lot to note their absence, and this being so, I am naturally sceptical as to the statement, especially when I hve found students at a loss to find them when the body has been before me, whilst on a stricter search they have been discovered mutilated by the act of manipulation, having, perhaps, previously undergone a softening process from decomposition. If, too, suppuration had existed, the organ would no doubt have been destroyed, for as soon as the abscess had been burst no trace of the organ would be left.

I may add that a brother of Mr Stedman saw the man who was the subject of this case, and he tells me the change in the colour of the skin was most remarkable.