Henry G___, æt. 33, farm-labourer, unmarried, states that he had gonorrhœa in November, 1858 ; was ill in March, 1859, which he attributes to extra work during the lambing season. He consulted the late Mr. Hammond, and was a week absent from his work. After resuming his occupation for two or three weeks he was again compelled to rest. He was no ordered to live as well as he could, and take cod-liver oil. On this occasion he was away from work for three weeks, and then returned to his occupation, and continued until the end of June, since which time he has been unable to work. At this time I saw him ; he complained of weakness, loss of appetite, nausea, occasional vomiting, pain at the epigastrium, bowels constipated. The colour of his hands and face was brown, which I thought might be caused by the hot weather, for he was not confined to the house. About August, 1859, I considered the case might be one of Addison’s disease. In the beginning of September, at my request, he was seen by a medical friend, who looked upon the case as hepatic disease.

This gentleman advised him to have as good diet as he could procure ; at the same time I had prescribed the Tinctura Ferri Sesquichloridi. After this I saw very little of him until February 26th, 1860, when he sent for me. I was now informed that he had been at home during the last five months, and was becoming weaker ; appetite bad ; at times feels sickly ; complains of pain a little to the left of the navel ; bowels rather constipated ; stools dark-coloured ; urine acid, lightish colour ; pulse 94, soft and feeble ; slight dulness on percussion below left clavicle ; sounds of heart feeble. The brown colour of the face and hands still continues ; over the chest it is almost natural, and becomes much darker over the abdomen and thighs ; whilst that of the penis and scrotum is a dingy black, which he has noticed for the last two years. There is also a dark ring round the umbilicus. No odour is perceptible about the body of the patient. I attended him for a short time, and he felt somewhat better.

I ws requested to see him on April 20th, when the chief symptoms requiring treatment were constipation and sickness, the latter being incessant for the last few days. He died on the evening of April 27th.

The inspection took place twenty hours after death. Mr. Ward, of Wellow, kindly assisted me. Rigor Mortis was well marked ; body somewhat wasted. Colour of skin lightest over legs and chest ; darkest on penis and scrotum. Portions of the organs, with the supra-renal capsules, I forwarded to Dr. Wilks, who favoured me with a note, from which I extract the following remarks:-

“I have no doubt that yours is a genuine example of the disease (Addison’s), and that the capsule which is now before me is a true specimen of the morbid change. It consists of a hard mass of fibro-albuminous tissue, degenerating in parts, exactly as we have seen before. The tissue is smooth, firm, and of a pinkish colour. When examined by the microscope, it is found to be composed of nucleated fibre. In the midst of this are some yellow,softer